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Ion channels are pore proteins that are involved in a large variety of physiological processes. Basic research in the ion channel field furthers the understanding of ion channel function as well as their roles within cellular pathways and processes.
Single-channel research helps with elucidating the mechanisms underlying ion channel function on a single-molecule level. Whole-cell and perforated patch clamp recordings are typically used to investigate the action of modulators on entire populations of ion channels in the membrane of a cell.
Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, neuronal communications, etc.
Ion channels play a role in many diseases, including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain and cancer. By understanding the exact role that ion channels play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease.
A critical part of drug discovery involves safety assessments, such as hERG testing, in order to eliminate any compounds with potential safety concerns. Conventional patch clamp has played an important role in collecting evidence for the absence of side effects before submission of a drug candidate to regulatory authorities.
Even if automated electrophysiology has shifted safety testing to earlier stages in the drug discovery process, follow-up with conventional patch clamp is an essential step in the workflow. Telegraphing between the software and the amplifier ensure correct scaling and logging of experimental parameters. Email address:. Axopatch B Patch Clamp Amplifier. Add to quote list. Category: Patch Clamp Amplifiers. Overview Applications Software Specifications Order Overview For single-channel recording, whole-cell voltage- and current-clamp recordings, extracellular field potential recordings in ion channel, neuroscience, nanopore, voltammetry studies.
Incorporates capacitor-feedback technology and active headstage cooling for single-channel recording, while resistive-feedback circuitry is used for two different ranges of whole-cell recording. In current-clamp mode, offers two different speeds to optimize membrane potential recording, and allows correction for voltage errors due to pipette resistance.
This makes the Axopatch B System the amplifier of choice for a scientist who performs basic research in the ion channel field and is the reason why researchers purchased thousands of these amplifiers from Molecular Devices over the past decade.
Applications Basic Ion Channel Research. Cell Pathway Analysis. Disease Research. Safety Assessment. Specifications General Specifications Dimensions in. Order To order the Axopatch B amplifier please Call us at: or email us at: sales alascience. Related products. Show Details. MultiClamp B. Subscribe to our Newsletter Email address:. Search Site.
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